Regulation of Cardiac Growth and Development by SRF and Its Cofactors

Abstract

The generation of specialized cell types during development is dependent on combinatorial interactions between widely expressed and cell-type-restricted transcription factors that establish cell identity and coupleextracellular signals to specific programs of gene expression. The MADS (MCM1, Agamous, Deficiens, serumresponse factor) box family of transcription factors is especially illustrative of the importance of combinatorialcontrol in gene regulation during development (Shoreand Sharrocks 1995)...