Publication | Open Access
Discovery of a Potent and Orally Bioavailable CCR2 and CCR5 Dual Antagonist
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Citations
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References
2009
Year
Medicinal ChemistryPharmaceutical ScienceBiochemistryCcr2 PotencyMedicineNatural SciencesFunctional SelectivityImmunologyMechanism Of ActionPharmacotherapyNon-peptide LigandPharmacologyCcr5 Dual AntagonistOrally Bioavailable Ccr2Drug Discovery
This report describes the discovery of a potent, orally bioavailable CC chemokine receptor 2 (CCR2) antagonist which, while optimized for CCR2 potency, also had potent CC chemokine receptor 5 (CCR5) activity.
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