Sensing of Fatty Acids for Octanoylation of Ghrelin Involves a Gustatory G-Protein

Abstract

This study provides the first evidence that α-gustducin is involved in the octanoylation of ghrelin and shows that the ghrelin cell can sense long- and medium-chain fatty acids directly. GPR120 but not GPR40 may play a role in the lipid sensing cascade of the ghrelin cell.