Structural and Functional Brain Development After Hydrocortisone Treatment for Neonatal Chronic Lung Disease

Abstract

Prematurity is associated with mild brain structural differences that persist at 8 years of age, with associated lower scores in neurocognitive assessments. The data suggest that perinatal hydrocortisone given at the described dosage has no long-term effects on either neurostructural brain development or neurocognitive outcomes.