Evaluation of the clinical efficacy and safety of dexmedetomidine or medetomidine in cats and their reversal with atipamezole

Characterization of the selectivity, specificity and potency of medetomidine as an α2-adrenoceptor agonist

Raimo Virtanen, Juha‐Matti Savola, Veijo Saano et al. · European Journal of Pharmacology · 1988 · 701 citations

Medicine, Medicinal Chemistry, Pharmacology +7

Clinical effects and pharmacokinetics of medetomidine and its enantiomers in dogs

Kuusela, Marja Raekallio, Anttila et al. · Journal of Veterinary Pharmacology and Therapeutics · 2000 · 298 citations

Medicine, Pharmacokinetics, Pharmacology +13

Anesthetic and Hemodynamic Effects of the Stereoisomers of Medetomidine, an ??2-Adrenergic Agonist, in Halothane-Anesthetized Dogs

R. Vickery, Brett C. Sheridan, Ira S. Segal et al. · Anesthesia & Analgesia · 1988 · 145 citations

Medicine, Anesthesiology, Pharmacology +16

Comparison of three doses of dexmedetomidine with medetomidine in cats following intramuscular administration

Ansah, Marja Raekallio, Outi Vainio · Journal of Veterinary Pharmacology and Therapeutics · 1998 · 139 citations

Medicine, Pharmacology, Veterinary Pharmacology +12

Central α2-adrenoceptors are highly stereoselective for dexmedetomidine, the dextro enantiomer of medetomidine

Juha‐Matti Savola, Raimo Virtanen · European Journal of Pharmacology · 1991 · 137 citations

Medicine, Pharmacology, Pharmacodynamics +6