Central α2-adrenoceptors are highly stereoselective for dexmedetomidine, the dextro enantiomer of medetomidine

Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α ₂ -Adrenergic Receptor

Brian K. Kobilka, Hiroaki Matsui, Tong Sun Kobilka et al. · Science · 1987 · 789 citations

Life Sciences, Molecular Genetics, Pharmacology +11

Characterization of the selectivity, specificity and potency of medetomidine as an α2-adrenoceptor agonist

Raimo Virtanen, Juha‐Matti Savola, Veijo Saano et al. · European Journal of Pharmacology · 1988 · 701 citations

Medicine, Medicinal Chemistry, Pharmacology +7

Reduced Narcotic Requirement by Clonidine with Improved Hemodynamic and Adrenergic Stability in Patients Undergoing Coronary Bypass Surgery

Joan W. Flacke, B. C. Bloor, Werner Flacke et al. · Anesthesiology · 1987 · 448 citations · Full text

Medicine, Cardiology, Pharmacology +9

Studies on the relationship between chemical constitution and physiological action

Leslie Hilton Easson, Edgar Stedman · Biochemical Journal · 1933 · 447 citations · Full text

Natural Sciences, Chemistry, Physiology +6

Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.

John W. Regan, Tong Sun Kobilka, T L Yang-Feng et al. · Proceedings of the National Academy of Sciences · 1988 · 436 citations · Full text

Medicine, Molecular Biology, Pharmacology +13