Identification of Epitopes and Immunodominant Regions on the MICA Protein Defined by Alloantibodies From Kidney Transplant Patients

Abstract

The presence of anti-MICA Abs could be an important marker for diagnosis because of their contribution to the outcome of the graft, regardless of presence of anti-HLA Abs. Additionally, the identification of epitopes revealed the in vivo antigens of the transplant and is spurring the development of new matching strategies to reduce the incidence of acute and chronic rejection.