Antithrombotic effects by oral administration of novel proteinase fraction from earthworm eisenia andrei on venous thrombosis model in rats

Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-alpha, and transforming growth factor-beta.

Michael Sawdey, David J. Loskutoff · Journal of Clinical Investigation · 1991 · 411 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

Enhancement of the Fibrinolytic Activity in Plasma by Oral Administration of Nattokinase ^s

Hiroyuki Sumi, Hiroki Hamada, Kouichiro Nakanishi et al. · Acta Haematologica · 2009 · 305 citations

Medicine, Pharmacology, Pharmacotherapy +12

A Novel Fibrinolytic Enzyme Extracted from the Earthworm, Lumbricus rubellus.

Hisashi Mihara, Hiroyuki Sumi, Tomoyuki Yoneta et al. · The Japanese Journal of Physiology · 1991 · 263 citations · Full text

Life Sciences, Biochemistry, Biocatalysis +12

An improved method for washing of human platelets with prostacyclin

Marek Radomski, Salvador Moncada · Thrombosis Research · 1983 · 227 citations

Medicine, Hematology, Pharmacology +9

Characterization of Potent Fibrinolytic Enzymes in Earthworm, Lumbricus rubellus

Nobuyoshi Nakajima, Hisashi Mihara, Hiroyuki Sumi · Bioscience Biotechnology and Biochemistry · 1993 · 156 citations

Life Sciences, Biochemistry, Nutritional Sciences +10