Platelet‐Rich Plasma‐Derived Fibrin Clot Formation Stimulates Collagen Synthesis in Periodontal Ligament and Osteoblastic Cells In Vitro

Abstract

These findings demonstrated that the gel-like material formed in cell cultures of either PDL or MG63 cells is fibrin clot that is capable of up-regulating collagen synthesis in the extracellular matrix. Our data suggest the possibility that fibrinogen, converted to fibrin, in combination with growth factors present in PRP might effectively promote wound healing at sites of injury in periodontal tissue.