Platelet‐Rich Plasma Contains High Levels of Platelet‐Derived Growth Factor and Transforming Growth Factor‐β and Modulates the Proliferation of Periodontally Related Cells In Vitro

Abstract

These data demonstrated that both PDGF-AB and TGF-beta1 were highly concentrated in the PRP preparations. It is suggested PRP modulates cell proliferation in a cell type-specific manner similar to what has been observed with TGF-beta1. Since synchronized behavior of related cell types is thought to be required for successful periodontal regeneration, it is further suggested these cell type-specific actions may be beneficial for periodontal regenerative therapy.