Room Temperature Direct Alkynylation of 1,3,4-Oxadiazoles with Alkynyl Bromides under Copper Catalysis

Abstract

The direct alkynylation reaction of 1,3,4-oxadiazoles with alkynyl bromides efficiently proceeds in the presence of a copper catalyst at room temperature to create the corresponding heteroaryl-alkynyl linkage in good yields. This direct coupling provides a rapid and convergent access to oxadiazole core pi-conjugated systems.