Concepedia

High versus low dosing of oral colchicine for early acute gout flare: Twenty‐four–hour outcome of the first multicenter, randomized, double‐blind, placebo‐controlled, parallel‐group, dose‐comparison colchicine study

Robert Terkeltaub, Daniel E. Furst, Katherine Bennett, Karin A. Kook, R. S. Crockett, Matthew W. Davis

Arthritis & Rheumatism · 2010 · 520 citations · 17 references

DOI

Abstract

Low-dose colchicine yielded both maximum plasma concentration and early gout flare efficacy comparable with that of high-dose colchicine, with a safety profile indistinguishable from that of placebo.

References

17

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Michael A. Becker, H. Ralph Schumacher, Robert L. Wortmann et al. · New England Journal of Medicine · 2005 · 1.3K citations · Full text

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Michael A. Becker, H. Ralph Schumacher, Robert L. Wortmann et al. · Arthritis & Rheumatism · 2005 · 267 citations