Low molecular weight inhibitors of Myc–Max interaction and function

A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy

Pavel G. Komarov, Elena A. Komarova, Roman V. Kondratov et al. · Science · 1999 · 1.3K citations

Medicine, Oncology, Pharmacology +17

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

Jialun Wang, Dongxiang Liu, Zhijia Zhang et al. · Proceedings of the National Academy of Sciences · 2000 · 1.2K citations

Life Sciences, Molecular Biology, Oncology +17

Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

Hilary A. Coller, Carla Grandori, Pablo Tamayo et al. · Proceedings of the National Academy of Sciences · 2000 · 827 citations

Life Sciences, Cell Biology, Molecular Biology +17

Pharmacological Rescue of Mutant p53 Conformation and Function

Barbara A. Foster, Heather A. Coffey, Michael J. Morin et al. · Science · 1999 · 801 citations

Medicine, Oncology, Pharmacology +13

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

Trevor D. Littlewood, David C. Hancock, Paul S. Danielian et al. · Nucleic Acids Research · 1995 · 789 citations · Full text

Life Sciences, Biochemistry, Endocrinology +16