Concepedia

Myc-max Dimerization

Myc-Max Dimerization is a molecular interaction mechanism in which the Myc oncoprotein heterodimerizes with its partner Max to form a transcriptionally active complex that binds to E-box DNA elements, thereby enabling the regulation of genes involved in cell proliferation, growth, and apoptosis.

151

Publications

14.7K

Citations

667

Authors

207

Institutions

Publications per year

2017–2026

19

Parents

Publications

151

Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites

Antonis S. Zervos, Jenő Gyuris, Roger Brent · Cell · 1993 · 786 citations

, , +11

Mad: A heterodimeric partner for Max that antagonizes Myc transcriptional activity

Donald E. Ayer, Leo Kretzner, Robert N. Eisenman · Cell · 1993 · 712 citations

, , +9

Oncogenic activity of the c-Myc protein requires dimerization with Max

Bruno Amati, Mary W. Brooks, Naomi Levy-Strumpf et al. · Cell · 1993 · 575 citations

, , +14

X-Ray Structures of Myc-Max and Mad-Max Recognizing DNA

Satish K. Nair, S.K. Burley · Cell · 2003 · 552 citations · Full text

, , +10

Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max

Bruno Amati, Stephen Dalton, Mary W. Brooks et al. · Nature · 1992 · 476 citations

, , +14

1–5 of 151

Authors

667

  1. EV
    Edward V. Prochownik

    Children's Hospital of Pittsburgh, United States

    11 publications · 1.3K citations

    11

    h-index

  2. RN
    Robert N. Eisenman

    Fred Hutch Cancer Center, United States

    12 publications · 2.3K citations

    11

    h-index

  3. PL
    Pierre Lavigne

    Université de Sherbrooke, Canada

    9 publications · 387 citations

    9

    h-index

  4. HL
    Hartmut Land

    The Honourable Society of Lincoln's Inn, United Kingdom

    5 publications · 1.7K citations

    5

    h-index

  5. PK
    Peter K. Vogt

    Scripps Research Institute, United States

    5 publications · 631 citations

    5

    h-index

1–5 of 667

Institutions

207

  1. Fred Hutch Cancer Center

    Seattle, United States

    11 h-index

    37 publications

    7.2K citations

  2. Children's Hospital of Pittsburgh

    Pittsburgh, United States

    9 h-index

    26 publications

    3.1K citations

  3. Université de Sherbrooke

    Sherbrooke, Canada

    8 h-index

    38 publications

    878 citations

  4. UPMC Hillman Cancer Center

    Pittsburgh, United States

    6 h-index

    15 publications

    2.4K citations

  5. Scripps Research Institute

    San Diego, United States

    6 h-index

    24 publications

    3.7K citations

  6. Massachusetts General Hospital

    Boston, United States

    6 h-index

    14 publications

    2.8K citations

  7. Harvard University

    Cambridge, United States

    5 h-index

    15 publications

    3.3K citations

  8. Seoul National University

    Seoul, South Korea

    5 h-index

    21 publications

    537 citations

1–8 of 207

Venues

  1. PubMed

    Repository · 16 publications · 994 citations

    14

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 11 publications · 1.1K citations

    11

    h-index

  3. Genes & Development

    10 publications · 1.7K citations

    10

    h-index

  4. Journal of Biological Chemistry

    JBC · 8 publications · 462 citations

    8

    h-index

  5. Biochemistry

    8 publications · 332 citations

    8

    h-index

1–5