Pd(II)-Catalyzed P(O)R¹R²-Directed Asymmetric C–H Activation and Dynamic Kinetic Resolution for the Synthesis of Chiral Biaryl Phosphates

Abstract

An efficient method of Pd(II)-catalyzed P(O)R(1)R(2)-directed asymmetric C-H activation and dynamic kinetic resolution for synthesis of chiral phosphinate ligands has been performed and exhibits a wide scope of substrates and an excellent diastereomeric ratio (>95:5).