The Pediatric Infectious Disease Journal · 2009 · 81 citations · 14 references
Life SciencesGeneticsImmunologyAdaptive ImmunityImmunogeneticsInnate ImmunityAirway DiseasesInnate Immune ResponseInnate Immune Signaling PathwaysLung DevelopmentPediatric Airway DisordersRespiratory DiseaseDisease Susceptibility AnalysisInnate Immune DefectsInnate Immune FunctionInnate Immune Response GeneticsInnate Immune Signaling GenesRespiratory Viral PathogenesisViral BronchiolitisViral Susceptibility
Prematurity is a risk factor for severe respiratory syncytial virus bronchiolitis. We show that genetic factors in innate immune genes (IFNA13, IFNAR2, STAT2, IL27, NFKBIA, C3, IL1RN, TLR5), in innate and adaptive immunity (IFNG), and in airway remodeling genes (ADAM33 and TGFBR1), affect disease susceptibility to a different extent in preterm children, born with underdeveloped lungs, than in term children.
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Philippe Bonniaud, Peter J. Margetts, Martin Kolb et al. · American Journal of Respiratory and Critical Care Medicine · 2004 · 252 citations