Inhibitory effects of triptolide on titanium particle-induced osteolysis and receptor activator of nuclear factor-κB ligand-mediated osteoclast differentiation

The synovial-like membrane at the bone-cement interface in loose total hip replacements and its proposed role in bone lysis.

Steven R. Goldring, A L Schiller, Merrilee S. Roelke et al. · Journal of Bone and Joint Surgery · 1983 · 856 citations · Full text

Medicine, Orthopedic Surgery, Surgery +17

Nuclear Factor of Activated T-cells (NFAT) Rescues Osteoclastogenesis in Precursors Lacking c-Fos

Koichi Matsuo, Deborah L. Galson, Zhao Chen et al. · Journal of Biological Chemistry · 2004 · 573 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

XPB, a subunit of TFIIH, is a target of the natural product triptolide

Denis V. Titov, Benjamin Gilman, Qingli He et al. · Nature Chemical Biology · 2011 · 522 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +3

Tumor inhibitors. LXXIV. Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii

S. Morris Kupchan, William A. Court, Richard G. Dailey et al. · Journal of the American Chemical Society · 1972 · 510 citations

Medicine, Medicinal Chemistry, Pharmacology +6

Segregation of TRAF6‐mediated signaling pathways clarifies its role in osteoclastogenesis

Norihiko Kobayashi, Yuho Kadono, Asuka Naito et al. · The EMBO Journal · 2001 · 465 citations · Full text

Medicine, Cell Biology, Molecular Biology +12