Long-Term Pattern of Brain Natriuretic Peptide and N-Terminal Pro Brain Natriuretic Peptide and Its Determinants in the General Population: Contribution of Age, Gender, and Cardiac and Extra-Cardiac Factors

Abstract

Next to ageing and sex, a variety of changes in covariates reflecting the sequelae of cardiac remodelling as well as myocardial infarction and diabetes influence long-term changes of BNP and NT-proBNP. Of note, diabetes and increased BMI exert opposite effects. For interpretation of individual marker concentrations, a host of covariates needs to be considered, especially in subjects without prevalent or incident cardiac disease.