Reduction with age in methylcytosine in the promoter region −224∼−101 of the amyloid precursor protein gene in autopsy human cortex

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands.

Marianne Frommer, Louise E. McDonald, David Millar et al. · Proceedings of the National Academy of Sciences · 1992 · 3.3K citations

Life Sciences, Genetics, Molecular Biology +14

High sensitivity mapping of methylated cytosines

J.CIark Susan, Cheryl Paul, Marianne Frommer · Nucleic Acids Research · 1994 · 1.9K citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome

K. E. Wisniewski, Henryk M. Wı́sniewski, G. Y. Wen · Annals of Neurology · 1985 · 1.2K citations

Medicine, Neurology, Neuroscience +16

DNA Methylation Decreases in Aging But Not in Immortal Cells

Vincent L. Wilson, Peter A. Jones · Science · 1983 · 654 citations

Education, Cell Biology, Genetics +15

Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter.

Fujiko Watt, Peter L. Molloy · Genes & Development · 1988 · 599 citations · Full text

Life Sciences, Genetics, Molecular Biology +17