Journal of Dispersion Science and Technology · 2009 · 12 citations · 18 references
PharmacyChemistryPharmacokineticsNanomaterialsNanoparticle Drug DeliveryPhysical ChemistryLipid StructureLipid-based Drug Delivery SystemsLipid-based NanoparticlesNanoparticle CharacterizationNanoparticle DispersionsNanoparticle FormulationsAmorphous State CharacterizationCrystalline StructureLipid Nanoparticle CharacterizationLipid NanoparticlesLipid-based Drug CarriersPhysicochemical PropertiesRelease Mechanism AnalysisX-ray Diffraction Analysis
The effects of chloramphenicol on the characterization of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) have been studied in this work. Microemulsion technique of solid lipid above the melting point with or without liquid lipid was used to prepare NLC and SLN dispersions, respectively. The physicochemical properties of the carriers were investigated, such as the morphological, the crystalline structures of the particles by wide x-ray diffraction (WXRD), the crystal order by differential scanning calorimetry (DSC). The results indicate that the average diameters and zeta potentials of SLN and NLC with chloramphenicol were larger than those without chloramphenicol. DSC and WXRD analysis show that chloramphenicol in the lipid matrix of SLN and NLC is in an amorphous state. In vitro release studies were carried out to indicate that the liquid oil in the solid lipid leads to the low degree of crystallinity. It displays higher cumulative release rate. The release mechanism has been discussed.
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