Negative Regulation of Soluble Flt-1 and Soluble Endoglin Release by Heme Oxygenase-1

Abstract

The present study demonstrates that the HO-1/CO pathway inhibits sFlt-1 and sEng release, providing compelling evidence for a protective role of HO-1 in pregnancy, and identifies HO-1 as a novel target for the treatment of preeclampsia.