Imatinib analogs as potential agents for PET imaging of Bcr-Abl and c-KIT expression at a kinase level

The Protein Data Bank

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The PyMOL Molecular Graphics System

Warren L. DeLano · Medical Entomology and Zoology · 2002 · 18.1K citations

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Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571).

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Life Sciences, Medicinal Chemistry, Molecular Biology +13

Evaluation of the FLEXX incremental construction algorithm for protein-ligand docking

Bernd Krämer, Matthias Rarey, Thomas Lengauer · Proteins Structure Function and Bioinformatics · 1999 · 898 citations · Full text

Life Sciences, Bioinformatics, Medicinal Chemistry +17

Dasatinib (BMS-354825), a Dual SRC/ABL Kinase Inhibitor, Inhibits the Kinase Activity of Wild-Type, Juxtamembrane, and Activation Loop Mutant KIT Isoforms Associated with Human Malignancies

Marcus M. Schittenhelm, Sharon Shiraga, Arin Schroeder et al. · Cancer Research · 2006 · 467 citations

Medicine, Oncology, Pharmacology +16