MRI-Measurement of Perfusion and Glomerular Filtration in the Human Kidney With a Separable Compartment Model

Abstract

The separable compartment model is feasible for application in humans and sufficiently robust for a pixel analysis. Increased filtration values compared with the Patlak model suggest that the difference in accuracy observed in animal studies is relevant in humans. Increased perfusion values suggest that the separable compartment model corrects for known underestimations in the deconvolution analysis.