A Case of Extensive Subcutaneous Sarcoidosis

Abstract

Abstract A 61‐year‐old female with extensive subcutaneous epithelioid cell granuloma in the back and extremities had negative tuberculin reaction, positive anti‐nuclear factor (ANF) and elevated serum angiotensin‐converting enzyme (ACE) level while on oral clofibrate for one‐and‐a‐half years because of hyperlipemia. She also suffered from ischemic heart disease with pericardial effusion and dependent edema. The skin surface temperatures over the lesions were about 2°C higher than those of the surrounding normal skin. The subcutaneous lesions cleared spontaneously within 4 months after clofibrate was discontinued. Tuberculin reaction became positive and serum ACE returned to the normal level.