Concepedia

Verapamil prevents torsade de pointes by reduction of transmural dispersion of repolarization and suppression of early afterdepolarizations in an intact heart model of LQT3

Peter Milberg, Nico Reinsch, Nani Osada, Kristina Wasmer, Gerold Mönnig, J. Stypmann, G Breithardt, Wilhelm Haverkamp, Lars Eckardt

Basic Research in Cardiology · 2005 · 67 citations · 27 references

DOI

Concepts

References

27

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

Qing Wang, Jiaxiang Shen, Igor Splawski et al. · Cell · 1995 · 1.7K citations · Full text

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Early afterdepolarizations: mechanism of induction and block. A role for L-type Ca2+ current.

Craig T. January, Janet Riddle · Circulation Research · 1989 · 679 citations · Full text

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Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence.

Luc M. Hondeghem, Dirk J. Snyders · Circulation · 1990 · 610 citations · Full text

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Sodium Channel Block With Mexiletine Is Effective in Reducing Dispersion of Repolarization and Preventing Torsade de Pointes in LQT2 and LQT3 Models of the Long-QT Syndrome

Wataru Shimizu, Charles Antzelevitch · Circulation · 1997 · 529 citations

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Instability and Triangulation of the Action Potential Predict Serious Proarrhythmia, but Action Potential Duration Prolongation Is Antiarrhythmic

Luc M. Hondeghem, Leif Carlsson, Göran Duker · Circulation · 2001 · 505 citations

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