Planta Medica · 2006 · 13 citations · 0 references
Life SciencesCell BiologyImmunologyCell SignalingInflammationSignal TransductionCell Signaling NetworksEffector BiologyIge-mediated AllergyMast Cell ActivationMast Cell PharmacologyType I HypersensitivityIge Receptor SignalingIge-mediated ActivationMast Cell Degranulation InhibitionMast Cell Signaling PathwaysMek InhibitionMek InhibitorsProtein Tyrosine PhosphorylationTyrosine Phosphorylation Signaling
The molecular mechanism of how resveratrol inhibits mast cell degranulation was studied by examining its effects on the signaling components of the high affinity IgE receptor (FcepsilonRI) pathway. Resveratrol inhibited mast cell degranulation in a dose-dependent manner and reduced the FcepsilonRI-mediated tyrosine phosphorylation of ERK and PLCgamma1 but not of Syk and PLCgamma2. U-73 122 and PD98059, which are PLC and MEK inhibitors, also had inhibitory effects on mast cell degranulation. These results suggest that FcepsilonRI-mediated tyrosine phosphorylation of PLCgamma1 and ERK could be potential cellular targets of resveratrol for the inhibition of mast cell degranulation.