The dopamine receptor antagonist levo-tetrahydropalmatine attenuates heroin self-administration and heroin-induced reinstatement in rats

Heroin and cocaine intravenous self-administration in rats: Mediation by separate neural systems

Aaron Ettenberg, Hugh O. Pettit, Floyd E. Bloom et al. · Psychopharmacology · 1982 · 558 citations

Substance Abuse, Psychoactive Drug, Substance Use +12

Absence of opiate rewarding effects in mice lacking dopamine D2 receptors

Rafael Maldonado, Adolfo Saiardi, Olga Valverde et al. · Nature · 1997 · 439 citations

Addiction, Medicine, Opiate Rewarding Effects +9

Morphine reward in dopamine-deficient mice

Thomas S. Hnasko, Bethany N. Sotak, Richard D. Palmiter · Nature · 2005 · 335 citations

Substance Abuse, Behavioral Neuroscience, Addiction +9

Effects of opioid and dopamine receptor antagonists on relapse induced by stress and re-exposure to heroin in rats

Yavin Shaham, Jane Stewart · Psychopharmacology · 1996 · 200 citations

Substance Abuse, Substance Use, Addiction +10

Acute administration of the selective D₃ receptor antagonist SB‐277011A blocks the acquisition and expression of the conditioned place preference response to heroin in male rats

Charles R. Ashby, Mousumi Paul, Eliot L. Gardner et al. · Synapse · 2003 · 97 citations

Molecular Pharmacology, Substance Abuse, Behavioral Neuroscience +14