Silicon‐Based Building Blocks for One‐Step ¹⁸F‐Radiolabeling of Peptides for PET Imaging

Abstract

Radio-controlled landing of F: The facile 18F labeling of biomolecules has been achieved under mild conditions by using a unique silicon-based one-step approach (see scheme). A di-tert-butylsilyl derivative with an aryl linker was attached to a tetrapeptide. The assembly shows a hydrolytic stability that appears to be within the range required for in vivo positron emission tomography (PET) imaging applications.