Concepedia

<sup>18</sup>F‐Labeling of Peptides by means of an Organosilicon‐Based Fluoride Acceptor

Ralf Schirrmacher, G. Bradtmoller, Esther Schirrmacher, Oliver Thews, Julia Tillmanns, Thomas Siessmeier, Hans Georg Buchholz, Peter Bartenstein, Björn Wängler, Christof M. Niemeyer,

Angewandte Chemie International Edition · 2006 · 230 citations · 16 references

DOI

Concepts

Abstract

F on: Fluorotriorganosilyl-derivatized Tyr3-octreotate was labeled with 18F− providing the first practical formulation in 18F-radiochemistry for the labeling of a peptide (see scheme). The very mild reaction conditions and the fast labeling make this strategy a valuable tool for the synthesis of 18F-radiopharmaceuticals.

References

16

Multimeric Cyclic RGD Peptides as Potential Tools for Tumor Targeting: Solid‐Phase Peptide Synthesis and Chemoselective Oxime Ligation

Georgette Thumshirn, Ulrich Hersel, Simon L. Goodman et al. · Chemistry - A European Journal · 2003 · 267 citations

, , +17

Two-step methodology for high-yield routine radiohalogenation of peptides: (18)F-labeled RGD and octreotide analogs.

Thorsten Poethko, Margret Schottelius, Georgette Thumshirn et al. · PubMed · 2004 · 228 citations

, , +17

Utilization of Tetrabutylammonium Triphenylsilyldifluoride as a Fluoride Source for Nucleophilic Fluorination

Anthony S. Pilcher, Herman L. Ammon, Philip DeShong · Journal of the American Chemical Society · 1995 · 222 citations

, , +5

Comparison of (111)In-labeled somatostatin analogues for tumor scintigraphy and radionuclide therapy.

M. de Jong, W A Breeman, WH Bakker et al. · PubMed · 1998 · 210 citations

, , +15

Aryltrimethylammonium trifluoromethanesulfonates as precursors to aryl [<sup>18</sup>F]fluorides: Improved synthesis of [<sup>18</sup>F]GBR‐13119

Michael Haka, Michael R. Kilbourn, G. Leonard Watkins et al. · Journal of Labelled Compounds and Radiopharmaceuticals · 1989 · 180 citations

, , +10