¹⁸F‐Labeling of Peptides by means of an Organosilicon‐Based Fluoride Acceptor

Abstract

F on: Fluorotriorganosilyl-derivatized Tyr3-octreotate was labeled with 18F− providing the first practical formulation in 18F-radiochemistry for the labeling of a peptide (see scheme). The very mild reaction conditions and the fast labeling make this strategy a valuable tool for the synthesis of 18F-radiopharmaceuticals. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z600795_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.