Maternal serum vitamin B₁₂, folate and homocysteine and the risk of neural tube defects in the offspring in a high-risk area of China

Abstract

Lower serum concentrations of folate and vitamin B12 are related to the increased risk of NTD in high-risk populations. Both folate and vitamin B12 intake insufficiency could contribute to the increased risk of NTD. A dietary supplement, combining folate and vitamin B12, might be an effective measure to decrease the NTD incidence in these areas.