Norfluoxetine Enantiomers as Inhibitors of Serotonin Uptake in Rat Brain

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: Radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (−)[125I]iodocyanopindolol, [3H]mesulergine and [3H]Ketanserin

Daniël Hoyer, G. Engel, Hans O. Kalkman · European Journal of Pharmacology · 1985 · 577 citations

Life Sciences, Neuroscience, Pharmacology +13

A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-Trifluoromethylphenoxy)-n-methyl-3-phenylpropylamine

David T. Wong, Jong S. Horng, Frank P. Bymaster et al. · Life Sciences · 1974 · 477 citations

Medicine, Medicinal Chemistry, Pharmacology +10

A new selective inhibitor for uptake of serotonin into synaptosomes of rat brain: 3-(p-trifluoromethylphenoxy). N-methyl-3-phenylpropylamine.

Dawn M. Wong, Frank P. Bymaster, Jong S. Horng et al. · Journal of Pharmacology and Experimental Therapeutics · 1975 · 370 citations

Medicine, Neurobiology, Pharmacology +15

Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin.

B. Kenneth Koe, Arthur D. Weissman, W. M. WELCH et al. · Journal of Pharmacology and Experimental Therapeutics · 1983 · 258 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9