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Correlation between Compartmental Tenofovir Concentrations and an Ex Vivo Rectal Biopsy Model of Tissue Infectibility in the RMP-02/MTN-006 Phase 1 Study

DOIFull Paper Access

30

Citations

14

References

2014

Year

Nicola Richardson‐Harman, Craig W. Hendrix, Namandjé N. Bumpus, Christine Mauck, Ross Cranston, Kuo H. Yang, Julie Elliott, Karen Tanner, Ian McGowan, Angela D. M. Kashuba,
PLoS ONE

Abstract

The TFVdp MMC compartment (CD4+, CD4- and Total) provided the best surrogate for biopsy infectibility and the 7-daily topical TFV gel treatment provided the strongest PK profile for HIV suppression. ClinicalTrials.gov NCT00984971.

References

YearCitations

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