Concepedia

The relationships between oxidase and synthase activities of flavin dependent thymidylate synthase (FDTS)

Anatoly Chernyshev, Todd Fleischmann, Eric M. Koehn, Scott A. Lesley, Amnon Kohen

Chemical Communications · 2007 · 16 citations · 14 references

DOIFull text

Open access

Concepts

Abstract

New findings lead to a revised understanding of the substrates' binding order, the role of the substrate as an activator, and the observed lag phase in the FDTS catalyzed reaction.

References

14

A Stable Nonfluorescent Derivative of Resorufin for the Fluorometric Determination of Trace Hydrogen Peroxide: Applications in Detecting the Activity of Phagocyte NADPH Oxidase and Other Oxidases

Mingjie Zhou, Zhenjun Diwu, Nataliya Panchuk-Voloshina et al. · Analytical Biochemistry · 1997 · 1.4K citations

, , +17

Kinetics and Mechanism of Action of Glucose Oxidase

Quentin Gibson, BENNETT E. P. SWOBODA, Vincent Massey · Journal of Biological Chemistry · 1964 · 538 citations · Full text

, , +16

Structural genomics of the <i>Thermotoga maritima</i> proteome implemented in a high-throughput structure determination pipeline

Scott A. Lesley, Peter Kühn, Adam Godzik et al. · Proceedings of the National Academy of Sciences · 2002 · 377 citations · Full text

, , +14

An Alternative Flavin-Dependent Mechanism for Thymidylate Synthesis

Hannu Myllykallio, Gérard Lipowski, Damien Leduc et al. · Science · 2002 · 289 citations

, , +17

Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein

Irimpan I. Mathews, Ashley M. Deacon, Jaume M. Cánaves et al. · Structure · 2003 · 88 citations · Full text

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