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Nucleoside H-Phosphonates. V. The Mechanism of Hydrogenphosphonate Diester Formation Using Acyl Chlorides as Coupling Agents in Oligonucleotide Synthesis by the Hydrogenphosphonate Approach
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1987
Year
H-phosphono-acyl Mixed AnhydridesNucleic Acid ChemistryCross-coupling ReactionBiochemistryNatural SciencesOligonucleotideMolecular BiologyDna ReplicationHydrogenphosphonate ApproachOrganic ChemistryType IiiStereoselective SynthesisChemistryOligonucleotide SynthesisAcyl Chlorides
Abstract The H-phosphono-acyl mixed anhydrides of type III were found to be the main intermediates during H-phosphonate diester formation using acyl chlorides as coupling agents in the reaction of hydrogenphosphonate monoesters with hydroxylic components.