Concepedia

Nucleoside H-Phosphonates. V. The Mechanism of Hydrogenphosphonate Diester Formation Using Acyl Chlorides as Coupling Agents in Oligonucleotide Synthesis by the Hydrogenphosphonate Approach

Per J. Garegg, Tor Regberg, Jacek Stawiński, Roger Strömberg

Nucleosides Nucleotides & Nucleic Acids · 1987 · 54 citations · 0 references

Concepts

PharmacyBiochemistryChemistryNucleic Acid ChemistryOrganic ChemistryCross-coupling ReactionsNucleic Acid SynthesisNucleobase ChemistryOligonucleotide ChemistryOrganic SynthesisCoupling Reagent ChemistryH-phosphonate SynthesisMixed AnhydridesOligonucleotide Coupling ReactionsOligonucleotide Synthesis

Abstract

Abstract The H-phosphono-acyl mixed anhydrides of type III were found to be the main intermediates during H-phosphonate diester formation using acyl chlorides as coupling agents in the reaction of hydrogenphosphonate monoesters with hydroxylic components.