Sodium selenite induces apoptosis in acute promyelocytic leukemia-derived NB4 cells by a caspase-3-dependent mechanism and a redox pathway different from that of arsenic trioxide

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Life Sciences, Cell Biology, Molecular Biology +12

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

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Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

Akira Kakizuka, Wilson H. Miller, Kazuhiko Umesono et al. · Cell · 1991 · 1.5K citations · Full text

Life Sciences, Genetics, Molecular Biology +11

Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients

Zhixiang Shen, Guoqiang Chen, Jian-Hua Ni et al. · Blood · 1997 · 1.4K citations

Medicine, Pharmacokinetics, Pharmacology +17

Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

Emily H. Cheng, David G. Kirsch, Rollie J. Clem et al. · Science · 1997 · 1.1K citations

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