Mir-17-5P Promotes Migration of Human Hepatocellular Carcinoma Cells Through the P38 Mitogen-Activated Protein Kinase-Heat Shock Protein 27 Pathway

Abstract

Our findings suggest that the p38 MAPK pathway plays a crucial role in miR-17-5p-induced phosphorylation of HSP27 and, as a consequence, phosphorylated HSP27 enhances the migration of HCC cells. Our data highlight an important role of miR-17-5p in the proliferation and migration of HCC cells and support the potential application of miR-17-5p in HCC therapy.