A Polycistronic MicroRNA Cluster, <i>miR-17-92</i> , Is Overexpressed in Human Lung Cancers and Enhances Cell Proliferation

Yoji Hayashita, Hirotaka Osada, Yoshio Tatematsu, +7

Cancer Research

Reduced expression of <i>Dicer</i> associated with poor prognosis in lung cancer patients

Yoko Karube, Hisaaki Tanaka, Hirotaka Osada, +8

Cancer Science

Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients

Hirotaka Osada, Yoshio Tatematsu, Hiroko Saito, +3

International Journal of Cancer

Histone ModificationsEpigenetic ChangePathologyEpigeneticsTumor Biology +17

Frequent and histological type-specific inactivation of 14-3-3σ in human lung cancers

Hirotaka Osada, Yoshio Tatematsu, Yasushi Yatabe, +6

Oncogene

OncologyHuman Lung CancersHistological Type-specific InactivationMedicinePathology +6

<i>miR-375</i> Is Activated by ASH1 and Inhibits YAP1 in a Lineage-Dependent Manner in Lung Cancer

Eri Nishikawa, Hirotaka Osada, Yasumasa Okazaki, +10

Cancer Research

GeneticsLineage-dependent MannerTumor BiologyLung CancersTranscriptional Regulation +16

Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers

Kotaro Mizuno, Hirotaka Osada, Hiroyuki Konishi, +5

Oncogene

Aberrant HypermethylationChromatinHuman Lung CancersMedicineCancer Genomics +10

<i>ASH1</i> Gene Is a Specific Therapeutic Target for Lung Cancers with Neuroendocrine Features

Hirotaka Osada, Yoshio Tatematsu, Yasushi Yatabe, +2

Cancer Research

Significant growth inhibition of human lung cancer cells both in vitro and in vivo by the combined use of a selective cyclooxygenase 2 inhibitor, JTE-522, and conventional anticancer agents.

Toyoaki Hida, Ken‐ichi Kozaki, Hidemi Ito, +7

PubMed

ImmunologyPharmacotherapyTumor BiologyOncologySelective Cox-2 Inhibitor +15

YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation

Toshihiko Yokoyama, Hirotaka Osada, Hideki Murakami, +9

Carcinogenesis

Mesothelioma DevelopmentGliomaPathologyCancer GenomicsTumor Suppressor +10

Roles of Achaete-Scute Homologue 1 in DKK1 and E-cadherin Repression and Neuroendocrine Differentiation in Lung Cancer

Hirotaka Osada, Shuta Tomida, Yasushi Yatabe, +6

Cancer Research