Variations in DNA elucidate molecular networks that cause disease

Complement Factor H Polymorphism in Age-Related Macular Degeneration

Robert J. Klein, Caroline J. Zeiss, Emily Y. Chew et al. · Science · 2005 · 4.5K citations

Medicine, Immunology, Ophthalmology +14

A Common Variant in the <i>FTO</i> Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

Timothy M. Frayling, Nicholas J. Timpson, Michael N. Weedon et al. · Science · 2007 · 4.5K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Hierarchical Organization of Modularity in Metabolic Networks

A. L. Somera, D. A. Mongru, Zoltán N. Oltvai et al. · Science · 2002 · 4.3K citations · Full text

Life Sciences, Biochemistry, Systems Biology +15

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Warren J. Strittmatter, Ann M. Saunders, D. E. Schmechel et al. · Proceedings of the National Academy of Sciences · 1993 · 4.3K citations · Full text

Life Sciences, Genetics, Neurology +17

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

Samuel D. Wright, Robert Ramos, Peter S. Tobias et al. · Science · 1990 · 4K citations

Life Sciences, Biochemistry, Immunology +16