Imidazolium-based warheads strongly influence activity of water-soluble peptidic transglutaminase inhibitors

The Amber biomolecular simulation programs

David A. Case, Thomas E. Cheatham, Tom Darden et al. · Journal of Computational Chemistry · 2005 · 9.6K citations · Full text

Natural Sciences, Biophysics, Chemistry +17

Transglutaminase 2 Undergoes a Large Conformational Change upon Activation

Daniel M. Pinkas, Pavel Strop, Axel T. Brünger et al. · PLoS Biology · 2007 · 445 citations · Full text

Life Sciences, Biochemistry, Biology +16

Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity

Shenping Liu, Richard A. Cerione, Jon Clardy · Proceedings of the National Academy of Sciences · 2002 · 314 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10

Transglutaminase Inhibition Reduces Fibrosis and Preserves Function in Experimental Chronic Kidney Disease

Timothy S. Johnson, Marie Fisher, J. Haylor et al. · Journal of the American Society of Nephrology · 2007 · 126 citations

Medicine, Biochemistry, Pathology +17

Transglutaminase Inhibition by 2-[(2-Oxopropyl)thio]imidazolium Derivatives: Mechanism of Factor XIIIa Inactivation

Kurt Freund, K Doshi, Stanley L. Gaul et al. · Biochemistry · 1994 · 108 citations

Life Sciences, Biochemistry, Pharmacology +7