ANTITUMOR ANTIBIOTICS PRODUCED BY PENICILLIUM STIPITATUM THOM

Abstract

A new crystalline antibiotic designated PSX-1 has been isolated from the fermentation broth of Penicillium stipitarum THOM. Antibiotic PSX-1 is a neutral reddish substance melting at 33-34°C, containing only C, H and O. (λmax. 207 and 270 nm in methanol). The other crystalline antibiotic identified as duclauxin was isolated from the filtrate of the above-mentioned strain. Both antibiotics showed an inhibitory effect on EHRLICH ascites carcinoma (EAC), lymphadenoma L-5178 and sarcoma 37.