Click Chemistry on Azidoproline: High‐Affinity Dual Antagonist for HIV‐1 Envelope Glycoprotein gp120

Abstract

High affinity dual antagonist: The envelope glycoprotein gp120 of HIV-1 mediates the first steps of viral entry into the host cell. An azidoproline-based peptide conjugate 1 blocks the interaction of gp120 with both the CD4 cell-surface receptor and 17b (an antibody surrogate of the CCR5 co-receptor). It represents a potentially effective approach in preventing HIV infection. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2452/2006/z500037_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.