Parallel regulation of extracellular ATP and inorganic pyrophosphate: Roles of growth factors, transduction modulators, and ANK

Abstract

Modulation of eATP by various factors paralleled their effects on ePPi production, suggesting a shared pathway of ePPi and eATP production and implicating ANK in eATP transport. As eATP directly contributes to pathologic mineralization in articular cartilage, understanding eATP regulation may lead to effective therapies for crystal-associated arthritis.