Concepedia

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Antiviral Tannins from Two Phyllanthus Species

DOI

64

Citations

0

References

1999

Year

Karin C. S. Chen Liu, Mei-Tsu Lin, Shoei‐Sheng Lee, Jwo-Farn Chiou, Shijun Ren, Eric J. Lien
Planta Medica

Abstract

Seven ellagitannins isolated from Phyllanthus myrtifolius and P. urinaria (Euphorbiaceae) have been shown, for the first time, to be active against Epstein-Barr virus DNA polymerase (EBV-DP) at the microM level. All these compounds have the same moiety of a corilagin, and differ from each other by different substitutions at C-2 and C-4 of the glucose core. SAR analysis and molecular modeling reveal that the essential pharmacophore of these tannins resides in the corilagin moiety. The outer complex carboxylic acid moieties appear to act only as auxopharmacore.