Natural-like function in artificial WW domains

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

Julie Thompson, Desmond G. Higgins, Toby J. Gibson · Nucleic Acids Research · 1994 · 64.9K citations · Full text

Life Sciences, Bioinformatics, Sequence Analysis +14

Design of a Novel Globular Protein Fold with Atomic-Level Accuracy

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Life Sciences, Biochemistry, Bioinformatics +15

Evolutionarily Conserved Pathways of Energetic Connectivity in Protein Families

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Life Sciences, Bioinformatics, Evolutionary Biology +16

De Novo Protein Design: Fully Automated Sequence Selection

Bassil I. Dahiyat, Stephen L. Mayo · Science · 1997 · 1.2K citations

Life Sciences, Bioinformatics, Computational Design +15

Evolutionarily conserved networks of residues mediate allosteric communication in proteins

Gürol M. Süel, Steve W. Lockless, Mark A. Wall et al. · Nature Structural Biology · 2002 · 835 citations

Life Sciences, Biochemistry, Molecular Biology +8