Use of the Vibrio cholerae irgA gene as a locus for insertion and expression of heterologous antigens in cholera vaccine strains

A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR

Virginia L. Miller, John J. Mekalanos · Journal of Bacteriology · 1988 · 2.1K citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Construction of an eae deletion mutant of enteropathogenic Escherichia coli by using a positive-selection suicide vector

Michael S. Donnenberg, James B. Kaper · Infection and Immunity · 1991 · 1.1K citations · Full text

Life Sciences, Genetics, Microbiology +15

Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin.

Robert K. Taylor, Virginia L. Miller, D Furlong et al. · Proceedings of the National Academy of Sciences · 1987 · 1.1K citations · Full text

Life Sciences, Microbiology, Molecular Biology +17

Toxin, toxin-coregulated pili, and the toxR regulon are essential for Vibrio cholerae pathogenesis in humans.

D A Herrington, R. H. Hall, G Losonsky et al. · The Journal of Experimental Medicine · 1988 · 717 citations · Full text

Life Sciences, Genetics, Microbiology +17

Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development

John J. Mekalanos, Gregory D. Pearson, Nigel Harford et al. · Nature · 1983 · 638 citations · Full text

Life Sciences, Microbiology, Molecular Biology +16