Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 2: SAR of the acetylenic P1′ group

Human tumor necrosis factor. Production, purification, and characterization.

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Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis

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Medicine, Molecular Biology, Pathology +17

Crystal structure of the catalytic domain of human tumor necrosis factor-α-converting enzyme

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