Protection by Sulfur Compounds against the Air Pollutants Ozone and Nitrogen Dioxide

Abstract

Two distinct but related pathways of protection against the lethal effects of ozone and nitrogen dioxide are shown by (i) simultaneous inhalation of compounds that furnish -SH or -SS-, or both, and (ii) by injection of thiourea derivatives several days prior to exposure to these oxidant gases. The mechanism of (i) is believed similar to that proposed for the action of radiation-protective compounds; that of (ii) involves the development of a tolerance initiated by the thiourea against the oxidants.