Tissue Manganese Concentrations and Antioxidant Enzyme Activities in Rats Given Total Parenteral Nutrition With and Without Supplemental Manganese

Abstract

Supplemental parenteral manganese is taken up to a greater extent by peripheral tissues than the liver. In this first report of antioxidant enzyme activities in animals maintained with TPN, we found that TPN as well as supplemental manganese can influence antioxidant enzyme activities. We conclude that it is generally unnecessary and potentially toxic to supplement TPN solutions with manganese during short-term usage.