<i>tert</i>‐Alkylation of Ketones and Aldehydes

Abstract

α-Alkylation of carbonyl compounds (1) via the corresponding base cannot be used for the introduction of tert-alkyl groups. This important CC coupling reaction has now been accomplished by a route involving (2), which is allowed to react with tert-alkyl chloride in the presence of TiCl4, FeCl3, or ZnCl2.