LOCALIZATION OF CONSTITUTIVE NITRIC OXIDE SYNTHASE ISOFORMS AND THE NITRIC OXIDE TARGET ENZYME SOLUBLE GUANYLYL CYCLASE IN THE HUMAN BLADDER

Abstract

The distribution of constitutive nitric oxide synthase isoforms and soluble guanylyl cyclase provides evidence of nitric oxide-cyclic guanosine monophosphate mediated regulation of detrusor smooth muscle relaxation, neurotransmission and blood flow. Furthermore, the urothelium may also be a target of nitric oxide.